Assay Detail
Functional
CHEMBL4276507
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Antiviral activity against Influenza A virus A/duck/Guangdong/674/2014(H5N6) infected in chicken embryo fibroblasts assessed as reduction in cytopathic effect after 48 hrs by CCK-8 assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 5.54 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.51 |
| CHEMBL4282553 | — | — | 1 | 6.50 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 6.36 |
| CHEMBL4287425 | — | — | 1 | 6.28 |
| CHEMBL4278505 | — | — | 1 | 5.95 |
| CHEMBL4284614 | — | — | 1 | 5.94 |
| CHEMBL4276773 | — | — | 1 | 5.92 |
| CHEMBL4293639 | — | — | 1 | 5.91 |
| CHEMBL4291818 | — | — | 1 | 5.76 |
| CHEMBL4292761 | — | — | 1 | 5.76 |
| CHEMBL4285941 | — | — | 1 | 5.74 |
| CHEMBL4285767 | — | — | 1 | 5.71 |
| CHEMBL4276674 | — | — | 1 | 5.61 |
| CHEMBL4288395 | — | — | 1 | 5.59 |
| CHEMBL4281970 | — | — | 1 | 5.47 |
| CHEMBL4289163 | — | — | 1 | 5.47 |
| CHEMBL4292880 | — | — | 1 | 5.42 |
| CHEMBL4278685 | — | — | 1 | 5.33 |
| CHEMBL4285398 | — | — | 1 | 5.31 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.30 |
| CHEMBL4292576 | — | — | 1 | 5.25 |
| CHEMBL4282153 | — | — | 1 | 5.19 |
| CHEMBL4285029 | — | — | 1 | 5.09 |
| CHEMBL4293832 | — | — | 1 | 4.89 |
| CHEMBL4289349 | — | — | 1 | 4.83 |
| CHEMBL4290421 | — | — | 1 | 4.75 |
| CHEMBL4277442 | — | — | 1 | 4.75 |
| CHEMBL4277758 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4282553 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4287425 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4278505 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4284614 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4276773 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4293639 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4291818 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4292761 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4285941 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4285767 | — | EC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4276674 | — | EC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4288395 | — | EC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL4281970 | — | EC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL4289163 | — | EC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4292880 | — | EC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL4278685 | — | EC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL4285398 | — | EC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL4292576 | — | EC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL4282153 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4285029 | — | EC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL4293832 | — | EC50 | = | 12960.0 | nM | 4.89 |
| CHEMBL4289349 | — | EC50 | = | 14820.0 | nM | 4.83 |
| CHEMBL4290421 | — | EC50 | = | 17560.0 | nM | 4.75 |
| CHEMBL4277442 | — | EC50 | = | 17980.0 | nM | 4.75 |
| CHEMBL4277758 | — | EC50 | = | 23870.0 | nM | 4.62 |