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Assay Detail

CHEMBL4276646

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Vasopressin V1a receptor (CHEMBL1889)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Receptor-Ligand Interaction Measured by Inductively Coupled Plasma Mass Spectrometry and Selenium Labeling.
Cheignon C, Cordeau E, Prache N, Cantel S, Martinez J, Subra G, Arnaudguilhem C, Bouyssiere B, Enjalbal C.
J Med Chem (2018) 61 : 10173 -10184
PubMed 30395477 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 3 9.28 9.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4278500 1 9.49
CHEMBL4289837 1 9.35
CHEMBL4294901 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4278500 Kd = 0.32 nM 9.49
CHEMBL4289837 Kd = 0.45 nM 9.35
CHEMBL4294901 Kd = 0.99 nM 9.00