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Compound Detail

CHEMBL4294901

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N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[Se][Se]C[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

Basic Information

ChEMBL ID CHEMBL4294901
Phase Preclinical
Structure Type MOL
InChI Key PDAPSPXIBPNITO-FRPRKMAFSA-N
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

1178.0
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C46H65N15O12Se2
MW 1178.04

Activity Summary

Kd 2 meas. best 9.22
Ki 2 meas. best 9.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1a receptor
CHEMBL1889
Kd 9.22 9.11 0.6 2
Vasopressin V1a receptor
CHEMBL1889
Ki 9.15 8.96 0.7 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30395477 10.1021/acs.jmedchem.8b01320 Vasopressin V1a receptor 5

Data from ChEMBL 36 via Core Engine