Assay Detail
Functional
CHEMBL4303083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
IC50 for antiviral activity against SARS-CoV-2 in the Vero E6 cell line at 48 h by immunofluorescence-based assay (detecting the viral NP protein in the nucleus of the Vero E6 cells).
57
Total Activities
57
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 5.72 | 8.18 |
| pIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303784 | — | — | 1 | 8.18 |
| CHEMBL1214827 | ONALESPIB | 2.0 | 1 | 6.81 |
| CHEMBL4303782 | ZOTATIFIN | 2.0 | 1 | 6.75 |
| CHEMBL1957266 | — | — | 1 | 6.71 |
| CHEMBL4303785 | — | — | 1 | 6.70 |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | 6.46 |
| CHEMBL53325 | — | — | 1 | 6.17 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 6.17 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 1 | 5.67 |
| CHEMBL1624459 | — | — | 1 | 5.67 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 5.55 |
| CHEMBL4303781 | — | — | 1 | 5.50 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 5.41 |
| CHEMBL415087 | CLOPERASTINE | 2.0 | 1 | 5.27 |
| CHEMBL3786230 | — | — | 1 | 5.17 |
| CHEMBL4109308 | — | — | 1 | 5.12 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 4.95 |
| CHEMBL4088272 | — | — | 1 | 4.94 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 4.58 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 4.39 |
| CHEMBL1423 | PIMOZIDE | 4.0 | 1 | 4.04 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | - |
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | - |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | - |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | - |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL222301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303784 | — | IC50 | = | 6.653 | nM | 8.18 |
| CHEMBL1214827 | ONALESPIB | IC50 | = | 154.88 | nM | 6.81 |
| CHEMBL4303782 | ZOTATIFIN | IC50 | = | 177.42 | nM | 6.75 |
| CHEMBL1957266 | — | IC50 | = | 192.75 | nM | 6.71 |
| CHEMBL4303785 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4073443 | TOMIVOSERTIB | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL53325 | — | IC50 | = | 677.64 | nM | 6.17 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL1624459 | — | IC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 2818.38 | nM | 5.55 |
| CHEMBL4303781 | — | IC50 | = | 3176.87 | nM | 5.50 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 3890.45 | nM | 5.41 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL3786230 | — | IC50 | = | 6760.83 | nM | 5.17 |
| CHEMBL4109308 | — | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL4088272 | — | IC50 | = | 11455.13 | nM | 4.94 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 26302.68 | nM | 4.58 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 40457.59 | nM | 4.39 |
| CHEMBL1423 | PIMOZIDE | IC50 | = | 91201.08 | nM | 4.04 |
| CHEMBL4297454 | ABBV-744 | IC50 | ~ | 3467368.5 | nM | - |
| CHEMBL430060 | APICIDIN | IC50 | = | 999684595.59 | nM | - |
| CHEMBL4128763 | — | IC50 | ~ | 602.56 | nM | - |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 7762471.17 | nM | - |
| CHEMBL590799 | CAMOSTAT | IC50 | ~ | 6760.83 | nM | - |
| CHEMBL1560 | CAPTOPRIL | IC50 | ~ | 389.05 | nM | - |
| CHEMBL3747513 | CB-5083 | IC50 | ~ | 4897.79 | nM | - |
| CHEMBL4303786 | — | IC50 | ~ | 47863.01 | nM | - |
| CHEMBL4303404 | PELABRESIB | IC50 | ~ | 645.65 | nM | - |
| CHEMBL178 | DAUNORUBICIN | IC50 | ~ | 213.8 | nM | - |
| CHEMBL715 | OLANZAPINE | IC50 | ~ | 18197.01 | nM | - |
| CHEMBL2170062 | — | IC50 | ~ | 140.28 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | ~ | 17988.71 | nM | - |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | ~ | 77.62 | nM | - |
| CHEMBL254578 | — | IC50 | ~ | 2089.3 | nM | - |
| CHEMBL52440 | DEXTROMETHORPHAN | IC50 | ~ | 7762.47 | nM | - |
| CHEMBL109 | VALPROIC ACID | IC50 | ~ | 121.06 | nM | - |
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 135831.34 | nM | - |
| CHEMBL2393130 | APABETALONE | IC50 | ~ | 1428.89 | nM | - |
| CHEMBL1789941 | RUXOLITINIB | IC50 | ~ | 7345.14 | nM | - |
| CHEMBL222301 | — | IC50 | ~ | 21134.89 | nM | - |
| CHEMBL31634 | BRIVUDINE | IC50 | ~ | 225423921.22 | nM | - |
| CHEMBL275707 | RIMCAZOLE | IC50 | = | 269153.48 | nM | - |
| CHEMBL1643 | RIBAVIRIN | IC50 | ~ | 81470.43 | nM | - |
| CHEMBL50 | QUERCETIN | IC50 | ~ | 2290.87 | nM | - |
| CHEMBL595 | PIOGLITAZONE | IC50 | ~ | 676.08 | nM | - |
| CHEMBL477772 | PAZOPANIB | IC50 | ~ | 1445439.77 | nM | - |
| CHEMBL296588 | PEPSTATIN | IC50 | ~ | 776.25 | nM | - |
| CHEMBL608533 | MIDOSTAURIN | IC50 | ~ | 336.51 | nM | - |