Assay Detail
Binding
CHEMBL4303093
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Displacement of [3H]-DTG from the Sigma2 receptor
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.95 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 8.60 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 1 | 7.60 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 7.02 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.30 |
| CHEMBL4088272 | — | — | 1 | 6.10 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL76 | CHLOROQUINE | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4088272 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | Ki | = | 1000.0 | nM | 6.00 |