Assay Detail
Binding
CHEMBL4303776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.56 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1626 | CLEMASTINE | 4.0 | 1 | 7.27 |
| CHEMBL53325 | — | — | 1 | 5.40 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 5.26 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.24 |
| CHEMBL4088272 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1626 | CLEMASTINE | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL53325 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | Ki | = | 5495.41 | nM | 5.26 |
| CHEMBL76 | CHLOROQUINE | Ki | = | 5754.4 | nM | 5.24 |
| CHEMBL4088272 | — | Ki | = | 24547.09 | nM | 4.61 |