Assay Detail
Functional
CHEMBL4303806
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Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 5.57 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103851 | AMUVATINIB | 2.0 | 1 | 7.70 |
| CHEMBL3989553 | NAFAMOSTAT MESYLATE | 3.0 | 1 | 7.40 |
| CHEMBL95431 | CARBOXYAMIDOTRIAZOLE | 3.0 | 1 | 7.05 |
| CHEMBL4303677 | — | — | 1 | 6.72 |
| CHEMBL71191 | — | — | 1 | 6.70 |
| CHEMBL1231723 | — | — | 1 | 6.66 |
| CHEMBL4788406 | VLX-600 | 1.0 | 1 | 6.62 |
| CHEMBL2171124 | — | — | 1 | 6.60 |
| CHEMBL2105698 | ALVOCIDIB HYDROCHLORIDE | 2.0 | 1 | 6.23 |
| CHEMBL2003538 | CETYLPYRIDINIUM CHLORIDE | 3.0 | 1 | 6.21 |
| CHEMBL2364622 | PEVONEDISTAT HYDROCHLORIDE | -1.0 | 1 | 6.20 |
| CHEMBL1316965 | ETHAVERINE HYDROCHLORIDE | -1.0 | 1 | 6.19 |
| CHEMBL85164 | CAMOSTAT MESILATE | 3.0 | 1 | 6.19 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 6.14 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 6.12 |
| CHEMBL4303661 | — | — | 1 | 6.11 |
| CHEMBL559569 | — | — | 1 | 6.11 |
| CHEMBL283078 | THIOGUANOSINE | — | 1 | 6.11 |
| CHEMBL2364627 | RALIMETINIB MESYLATE | -1.0 | 1 | 6.06 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 5.96 |
| CHEMBL1518572 | — | — | 1 | 5.87 |
| CHEMBL3181957 | ALMITRINE MESYLATE | -1.0 | 1 | 5.85 |
| CHEMBL1200485 | SORAFENIB TOSYLATE | 4.0 | 1 | 5.81 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 5.79 |
| CHEMBL36342 | OCTENIDINE HYDROCHLORIDE | 2.0 | 1 | 5.78 |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 5.78 |
| CHEMBL508338 | THIMEROSAL | 3.0 | 1 | 5.77 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 5.77 |
| CHEMBL317840 | HAEMAPORPHYRIN | — | 1 | 5.73 |
| CHEMBL152649 | CHLORMIDAZOLE | 2.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103851 | AMUVATINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3989553 | NAFAMOSTAT MESYLATE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL95431 | CARBOXYAMIDOTRIAZOLE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4303677 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL71191 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1231723 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4788406 | VLX-600 | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2171124 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2105698 | ALVOCIDIB HYDROCHLORIDE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2003538 | CETYLPYRIDINIUM CHLORIDE | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2364622 | PEVONEDISTAT HYDROCHLORIDE | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1316965 | ETHAVERINE HYDROCHLORIDE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL85164 | CAMOSTAT MESILATE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL70663 | DAPIVIRINE | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4065616 | REMDESIVIR | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4303661 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL283078 | THIOGUANOSINE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL559569 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2364627 | RALIMETINIB MESYLATE | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1518572 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3181957 | ALMITRINE MESYLATE | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1200485 | SORAFENIB TOSYLATE | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL36342 | OCTENIDINE HYDROCHLORIDE | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL508338 | THIMEROSAL | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL317840 | HAEMAPORPHYRIN | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL152649 | CHLORMIDAZOLE | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL550495 | METHYLENE BLUE | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL294029 | RAVUCONAZOLE | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL1651956 | ALISPORIVIR | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3188386 | WNT-974 | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL1277001 | MIBAMPATOR | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL101309 | AVASIMIBE | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL2103883 | AVATROMBOPAG | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL231779 | APIXABAN | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL1484738 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL1368758 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL551978 | DROTAVERINE | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL2105737 | SONIDEGIB | IC50 | = | 10670.0 | nM | 4.97 |
| CHEMBL3350262 | — | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL195789 | — | IC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL998 | LORATADINE | IC50 | = | 15130.0 | nM | 4.82 |