Compound Detail
CHEMBL1277001
MIBAMPATOR 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1277001 |
| Name | MIBAMPATOR |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ULRDYYKSPCRXAJ-KRWDZBQOSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
7
Publications
4
Known Names
1
Indications
1
Mechanisms
Molecular Properties
438.6
MW (Da)
2.88
ALogP
4
HBA
2
HBD
92.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | Glutamate receptor ionotropic AMPA | ✓ | ✓ |
Indications
Alzheimer Disease
Activity Summary
EC50 1 meas. best 6.82
IC50 1 meas. best 5.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 4 CHEMBL3190 | EC50 | 6.82 | 6.82 | 150.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 5.48 | 5.48 | 3280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 4 | EC50 | = | 150.0 | nM | 6.82 | Inhibition of GluR4 expressed in HEK293 cells | 20839777 |
| SARS-CoV-2 | IC50 | = | 3280.0 | nM | 5.48 | Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity o... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 20839777 | 10.1021/jm1000419 | Glutamate receptor 4 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | Caco-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | ADMET | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine