Assay Detail
Functional
CHEMBL4303826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.05 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | 4.0 | 1 | 5.39 |
| CHEMBL1357648 | AMODIAQUINE HYDROCHLORIDE | 4.0 | 2 | 5.31 |
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 5.27 |
| CHEMBL46516 | FLUSPIRILENE | 3.0 | 1 | 5.27 |
| CHEMBL187709 | TRIPARANOL | 4.0 | 1 | 5.19 |
| CHEMBL1200710 | CLOMIPRAMINE HYDROCHLORIDE | 4.0 | 1 | 5.12 |
| CHEMBL3989478 | THIETHYLPERAZINE MALEATE | 4.0 | 1 | 5.10 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 1 | 5.09 |
| CHEMBL786 | TAMOXIFEN CITRATE | 4.0 | 1 | 5.05 |
| CHEMBL1448187 | FLUPHENAZINE HYDROCHLORIDE | 4.0 | 1 | 5.05 |
| CHEMBL1200750 | PROMETHAZINE HYDROCHLORIDE | 4.0 | 1 | 4.98 |
| CHEMBL1200675 | TOREMIFENE CITRATE | 4.0 | 1 | 4.95 |
| CHEMBL1690 | HYDROXYCHLOROQUINE SULFATE | 4.0 | 1 | 4.95 |
| CHEMBL1714574 | TERCONAZOLE | 4.0 | 1 | 4.79 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | 4.0 | 1 | 4.75 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 4.33 |
| CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | — | 1 | - |
| CHEMBL423192 | ANISOMYCIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL1357648 | AMODIAQUINE HYDROCHLORIDE | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL1642 | IMATINIB MESYLATE | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL46516 | FLUSPIRILENE | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL1357648 | AMODIAQUINE HYDROCHLORIDE | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL187709 | TRIPARANOL | IC50 | = | 6410.0 | nM | 5.19 |
| CHEMBL1200710 | CLOMIPRAMINE HYDROCHLORIDE | IC50 | = | 7590.0 | nM | 5.12 |
| CHEMBL3989478 | THIETHYLPERAZINE MALEATE | IC50 | = | 8020.0 | nM | 5.10 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL786 | TAMOXIFEN CITRATE | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL1448187 | FLUPHENAZINE HYDROCHLORIDE | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL1200750 | PROMETHAZINE HYDROCHLORIDE | IC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL1690 | HYDROXYCHLOROQUINE SULFATE | IC50 | = | 11170.0 | nM | 4.95 |
| CHEMBL1200675 | TOREMIFENE CITRATE | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1714574 | TERCONAZOLE | IC50 | = | 16140.0 | nM | 4.79 |
| CHEMBL1200383 | BENZTROPINE MESYLATE | IC50 | = | 17790.0 | nM | 4.75 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | IC50 | - | — | - | |
| CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | IC50 | - | — | - | |
| CHEMBL423192 | ANISOMYCIN | IC50 | - | — | - |