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Assay Detail

CHEMBL4305232

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human SSAO expressed in CHO cells by MAO-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [copper-containing] 3 (CHEMBL3437)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.
Leung L, Niculescu-Duvaz D, Smithen D, Lopes F, Callens C, McLeary R, Saturno G, Davies L, Aljarah M, Brown M, Johnson L, Zambon A, Chambers T, Ménard D, Bayliss N, Knight R, Fish L, Lawrence R, Challinor M, Tang H, Marais R, Springer C.
J Med Chem (2019) 62 : 5863 -5884
PubMed 31070916 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 4.32 4.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4441173 1 4.32
CHEMBL4564517 1 4.31
CHEMBL4434955 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4441173 IC50 = 48000.0 nM 4.32
CHEMBL4564517 IC50 = 49000.0 nM 4.31
CHEMBL4434955 IC50 >= 100000.0 nM -