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Assay Detail

CHEMBL4305658

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Binding
Inhibition of alpha-glucosidase (unknown origin)
ChEMBL ↗
67
Total Activities
66
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Alpha glucosidase (CHEMBL3833502) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.
Dhameja M, Gupta P.
Eur J Med Chem (2019) 176 : 343 -377
PubMed 31112894 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 66 5.12 6.77
Ki 1 4.85 4.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4470451 — — 1 6.77
CHEMBL85398 THIAZOLIDINEDIONE 3.0 1 6.27
CHEMBL4593597 — — 1 6.27
CHEMBL4435180 — — 1 5.92
CHEMBL4473640 — — 1 5.70
CHEMBL4458470 — — 1 5.66
CHEMBL4465201 — — 1 5.66
CHEMBL4455386 — — 1 5.66
CHEMBL4451791 — — 1 5.66
CHEMBL4445451 — — 1 5.66
CHEMBL4540336 — — 1 5.66
CHEMBL4450847 — — 1 5.47
CHEMBL4473090 — — 1 5.37
CHEMBL4539984 — — 1 5.37
CHEMBL4464394 — — 1 5.37
CHEMBL4556170 — — 1 5.37
CHEMBL4474603 — — 1 5.37
CHEMBL4559187 — — 1 5.37
CHEMBL4526585 — — 1 5.37
CHEMBL4456998 — — 1 5.37
CHEMBL4440152 — — 1 5.37
CHEMBL4513806 — — 1 5.37
CHEMBL4441979 — — 1 5.37
CHEMBL4525900 — — 1 5.37
CHEMBL4590962 — — 1 5.37
CHEMBL4439503 — — 1 5.37
CHEMBL4472506 — — 1 5.37
CHEMBL4557896 — — 1 5.37
CHEMBL4520965 — — 1 5.37
CHEMBL177114 MALONIC ACID DIETHYL ESTER — 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4470451 — IC50 = 170.0 nM 6.77
CHEMBL85398 THIAZOLIDINEDIONE IC50 = 540.0 nM 6.27
CHEMBL4593597 — IC50 = 540.0 nM 6.27
CHEMBL4435180 — IC50 = 1200.0 nM 5.92
CHEMBL4473640 — IC50 = 2000.0 nM 5.70
CHEMBL4458470 — IC50 = 2200.0 nM 5.66
CHEMBL4465201 — IC50 = 2200.0 nM 5.66
CHEMBL4455386 — IC50 = 2200.0 nM 5.66
CHEMBL4451791 — IC50 = 2200.0 nM 5.66
CHEMBL4445451 — IC50 = 2200.0 nM 5.66
CHEMBL4540336 — IC50 = 2200.0 nM 5.66
CHEMBL4450847 — IC50 = 3400.0 nM 5.47
CHEMBL4474603 — IC50 = 4300.0 nM 5.37
CHEMBL4539984 — IC50 = 4300.0 nM 5.37
CHEMBL4464394 — IC50 = 4300.0 nM 5.37
CHEMBL4556170 — IC50 = 4300.0 nM 5.37
CHEMBL4559187 — IC50 = 4300.0 nM 5.37
CHEMBL4526585 — IC50 = 4300.0 nM 5.37
CHEMBL4456998 — IC50 = 4300.0 nM 5.37
CHEMBL4440152 — IC50 = 4300.0 nM 5.37
CHEMBL4441979 — IC50 = 4300.0 nM 5.37
CHEMBL4525900 — IC50 = 4300.0 nM 5.37
CHEMBL4590962 — IC50 = 4300.0 nM 5.37
CHEMBL4439503 — IC50 = 4300.0 nM 5.37
CHEMBL4473090 — IC50 = 4300.0 nM 5.37
CHEMBL4472506 — IC50 = 4300.0 nM 5.37
CHEMBL4557896 — IC50 = 4300.0 nM 5.37
CHEMBL4520965 — IC50 = 4300.0 nM 5.37
CHEMBL4513806 — IC50 = 4300.0 nM 5.37
CHEMBL177114 MALONIC ACID DIETHYL ESTER IC50 = 5000.0 nM 5.30
CHEMBL3891396 — Ki = 14000.0 nM 4.85
CHEMBL3891396 — IC50 = 15000.0 nM 4.82
CHEMBL3919478 — IC50 = 15000.0 nM 4.82
CHEMBL3923085 — IC50 = 15000.0 nM 4.82
CHEMBL3976877 — IC50 = 15000.0 nM 4.82
CHEMBL3910543 — IC50 = 15000.0 nM 4.82
CHEMBL3906188 — IC50 = 15000.0 nM 4.82
CHEMBL3968348 — IC50 = 15000.0 nM 4.82
CHEMBL3936073 — IC50 = 15000.0 nM 4.82
CHEMBL3896149 — IC50 = 15000.0 nM 4.82
CHEMBL3924165 — IC50 = 15000.0 nM 4.82
CHEMBL3901221 — IC50 = 15000.0 nM 4.82
CHEMBL3980621 — IC50 = 15000.0 nM 4.82
CHEMBL3901489 — IC50 = 15000.0 nM 4.82
CHEMBL3984954 — IC50 = 15000.0 nM 4.82
CHEMBL3900431 — IC50 = 15000.0 nM 4.82
CHEMBL3186053 — IC50 = 19000.0 nM 4.72
CHEMBL4554161 — IC50 = 20000.0 nM 4.70
CHEMBL4475632 — IC50 = 20000.0 nM 4.70
CHEMBL4451317 — IC50 = 20000.0 nM 4.70