Assay Detail
Binding
CHEMBL4305756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of tracer 222 from GST-tagged recombinant human AAK1 catalytic domain (1 to 510 amino acids) expressed in insect cells shaken for 30 secs and incubated for 1 hr by LanthaScreen Eu kinase binding assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.83 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439128 | — | — | 1 | 8.40 |
| CHEMBL4541962 | — | — | 1 | 8.37 |
| CHEMBL4442812 | — | — | 1 | 8.03 |
| CHEMBL4483684 | — | — | 1 | 7.73 |
| CHEMBL3102941 | — | — | 1 | 7.63 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.32 |
| CHEMBL4443908 | — | — | 1 | 7.14 |
| CHEMBL4444527 | — | — | 1 | 6.97 |
| CHEMBL4454007 | — | — | 1 | 6.83 |
| CHEMBL4524476 | — | — | 1 | 6.79 |
| CHEMBL4474078 | — | — | 1 | 6.74 |
| CHEMBL4461527 | — | — | 1 | 6.68 |
| CHEMBL4561278 | — | — | 1 | 6.64 |
| CHEMBL3334981 | — | — | 1 | 6.50 |
| CHEMBL4448513 | — | — | 1 | 6.42 |
| CHEMBL4515873 | — | — | 1 | 6.42 |
| CHEMBL4468845 | — | — | 1 | 6.41 |
| CHEMBL4475520 | — | — | 1 | 6.40 |
| CHEMBL4449852 | — | — | 1 | 6.38 |
| CHEMBL4529052 | — | — | 1 | 6.33 |
| CHEMBL4553067 | — | — | 1 | 6.21 |
| CHEMBL4471240 | — | — | 1 | 5.47 |
| CHEMBL4476807 | — | — | 1 | 5.35 |
| CHEMBL516312 | — | — | 1 | - |
| CHEMBL4456500 | — | — | 1 | - |
| CHEMBL4455428 | — | — | 1 | - |
| CHEMBL4450261 | — | — | 1 | - |
| CHEMBL4453393 | — | — | 1 | - |
| CHEMBL4590585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439128 | — | IC50 | = | 4.02 | nM | 8.40 |
| CHEMBL4541962 | — | IC50 | = | 4.32 | nM | 8.37 |
| CHEMBL4442812 | — | IC50 | = | 9.27 | nM | 8.03 |
| CHEMBL4483684 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL3102941 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL535 | SUNITINIB | IC50 | = | 47.4 | nM | 7.32 |
| CHEMBL4443908 | — | IC50 | = | 72.1 | nM | 7.14 |
| CHEMBL4444527 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4454007 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4524476 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4474078 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4461527 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL4561278 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3334981 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL4448513 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL4515873 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL4468845 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL4475520 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL4449852 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4529052 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL4553067 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL4471240 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4476807 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL516312 | — | IC50 | - | — | - | |
| CHEMBL4456500 | — | IC50 | - | — | - | |
| CHEMBL4455428 | — | IC50 | - | — | - | |
| CHEMBL4450261 | — | IC50 | - | — | - | |
| CHEMBL4453393 | — | IC50 | - | — | - | |
| CHEMBL4590585 | — | IC50 | - | — | - |