Assay Detail
Binding
CHEMBL4306964
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Inhibition of wild-type human full length NNMT expressed in Escherichia coli BL21(DE3) cells assessed as reduction in 1-methyl-nicotinamide formation pre-incubated for 10 mins followed by AdoMet and nicotinamide addition measured after 30 mins by UHP-HILIC/Q-TOF-MS analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.86 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454921 | — | — | 1 | 5.85 |
| CHEMBL4067973 | — | — | 1 | 5.36 |
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 4.90 |
| CHEMBL4520769 | — | — | 1 | 4.83 |
| CHEMBL4470754 | — | — | 1 | 4.76 |
| CHEMBL4218848 | — | — | 1 | 4.70 |
| CHEMBL4474988 | — | — | 1 | 4.63 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 4.45 |
| CHEMBL4576615 | — | — | 1 | 4.28 |
| CHEMBL4569298 | — | — | 1 | - |
| CHEMBL4461098 | — | — | 1 | - |
| CHEMBL4553512 | — | — | 1 | - |
| CHEMBL4521509 | — | — | 1 | - |
| CHEMBL4539356 | — | — | 1 | - |
| CHEMBL4438136 | — | — | 1 | - |
| CHEMBL4572944 | — | — | 1 | - |
| CHEMBL4472868 | — | — | 1 | - |
| CHEMBL4439579 | — | — | 1 | - |
| CHEMBL4471461 | — | — | 1 | - |
| CHEMBL4514305 | — | — | 1 | - |
| CHEMBL4579657 | — | — | 1 | - |
| CHEMBL4572555 | — | — | 1 | - |
| CHEMBL4455850 | — | — | 1 | - |
| CHEMBL4444296 | — | — | 1 | - |
| CHEMBL4469899 | — | — | 1 | - |
| CHEMBL4575365 | — | — | 1 | - |
| CHEMBL4459756 | — | — | 1 | - |
| CHEMBL4475755 | — | — | 1 | - |
| CHEMBL4554572 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454921 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4067973 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 12510.0 | nM | 4.90 |
| CHEMBL4520769 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4470754 | — | IC50 | = | 17450.0 | nM | 4.76 |
| CHEMBL4218848 | — | IC50 | = | 19810.0 | nM | 4.70 |
| CHEMBL4474988 | — | IC50 | = | 23410.0 | nM | 4.63 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL4576615 | — | IC50 | = | 52620.0 | nM | 4.28 |
| CHEMBL4569298 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4461098 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4553512 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4521509 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4539356 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4438136 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4572944 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4472868 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4439579 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4471461 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4514305 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4579657 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4572555 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4455850 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4444296 | — | IC50 | = | 111500.0 | nM | - |
| CHEMBL4469899 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4575365 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4459756 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4475755 | — | IC50 | = | 129900.0 | nM | - |
| CHEMBL4554572 | — | IC50 | > | 250000.0 | nM | - |