Assay Detail
Functional
CHEMBL4307075
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Antiproliferative activity against human GRANTA-519 cells assessed as reduction in cell viability supplemented with fresh medium containing compound every 3 days incubated for 10 days by CCK-8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Granta-519 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.99 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4539373 | — | — | 1 | 7.32 |
| CHEMBL4518534 | — | — | 1 | 7.22 |
| CHEMBL4548376 | — | — | 1 | 6.85 |
| CHEMBL4451469 | — | — | 1 | 6.57 |
| CHEMBL4475046 | — | — | 1 | - |
| CHEMBL4585395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4539373 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4518534 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4548376 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4451469 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4475046 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4585395 | — | IC50 | > | 1000.0 | nM | - |