Compound Detail
CHEMBL4475046
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COC(CNc1ncnc2c1ccn2[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)cc2)[C@@H](O)[C@H]1O)OC
Basic Information
| ChEMBL ID | CHEMBL4475046 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFXBSODSUAZMSY-NAIAOIPJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
464.9
MW (Da)
1.47
ALogP
10
HBA
4
HBD
131.1
PSA (Ų)
0.37
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PRMT5/MEP50 complex CHEMBL3137261 | IC50 | 6.75 | 6.75 | 177.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PRMT5/MEP50 complex | IC50 | = | 177.0 | nM | 6.75 | Inhibition of human recombinant PRMT5/MEP50 expressed in baculovirus infected Hi... | 31312404 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31312404 | 10.1021/acsmedchemlett.9b00074 | PRMT5/MEP50 complex | 1 |
| 31312404 | 10.1021/acsmedchemlett.9b00074 | Protein arginine N-methyltransferase 5 | 1 |
| 31312404 | 10.1021/acsmedchemlett.9b00074 | Granta-519 | 1 |
Data from ChEMBL 36 via Core Engine