Assay Detail
Binding
CHEMBL4307304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at NMDA receptor in rat CGN cells assessed as increase in intracellular calcium level incubated for 30 mins in presence of Fura-2AM followed by NMDA/glycine stimulation by fluorescence spectrometer analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.59 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4558495 | — | — | 1 | 6.05 |
| CHEMBL4471659 | — | — | 1 | 5.92 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.82 |
| CHEMBL3259988 | — | — | 1 | 5.72 |
| CHEMBL4469343 | — | — | 1 | 5.48 |
| CHEMBL4591167 | — | — | 1 | 5.47 |
| CHEMBL4438626 | — | — | 1 | 5.16 |
| CHEMBL4462369 | — | — | 1 | 5.08 |
| CHEMBL292314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4558495 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4471659 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL807 | MEMANTINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3259988 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4469343 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4591167 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4438626 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4462369 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL292314 | — | IC50 | - | — | - |