Assay Detail
ADMET
CHEMBL4307520
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Antiproliferative activity against human HEK293 cells measured after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Primaquine homodimers as potential antiplasmodial and anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.25 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.75 |
| CHEMBL4457829 | — | — | 1 | 5.65 |
| CHEMBL4437357 | — | — | 1 | 5.00 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | 4.0 | 1 | 4.96 |
| CHEMBL4472144 | — | — | 1 | 4.76 |
| CHEMBL4578079 | — | — | 1 | 4.58 |
| CHEMBL4563190 | — | — | 1 | 4.02 |
| CHEMBL4546538 | — | — | 1 | - |
| CHEMBL4455575 | — | — | 1 | - |
| CHEMBL4578273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4457829 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4437357 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | IC50 | = | 10960.0 | nM | 4.96 |
| CHEMBL4472144 | — | IC50 | = | 17470.0 | nM | 4.76 |
| CHEMBL4578079 | — | IC50 | = | 26380.0 | nM | 4.58 |
| CHEMBL4563190 | — | IC50 | = | 94900.0 | nM | 4.02 |
| CHEMBL4546538 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4455575 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4578273 | — | IC50 | >= | 100000.0 | nM | - |