Assay Detail
Binding
CHEMBL4308449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length TRKA expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assay
113
Total Activities
113
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lead identification and characterization of hTrkA type 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 113 | 5.06 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573890 | — | — | 1 | 7.05 |
| CHEMBL4553953 | — | — | 1 | 6.65 |
| CHEMBL4458913 | — | — | 1 | 6.58 |
| CHEMBL4467890 | — | — | 1 | 6.40 |
| CHEMBL4448181 | — | — | 1 | 6.27 |
| CHEMBL4466950 | — | — | 1 | 6.18 |
| CHEMBL4458775 | — | — | 1 | 6.17 |
| CHEMBL4449741 | — | — | 1 | 6.14 |
| CHEMBL4447061 | — | — | 1 | 6.08 |
| CHEMBL4468419 | — | — | 1 | 6.07 |
| CHEMBL4590914 | — | — | 1 | 6.01 |
| CHEMBL4520451 | — | — | 1 | 5.84 |
| CHEMBL4592814 | — | — | 1 | 5.80 |
| CHEMBL4518353 | — | — | 1 | 5.71 |
| CHEMBL4545062 | — | — | 1 | 5.63 |
| CHEMBL4437226 | — | — | 1 | 5.60 |
| CHEMBL4557960 | — | — | 1 | 5.60 |
| CHEMBL4584518 | — | — | 1 | 5.56 |
| CHEMBL4527557 | — | — | 1 | 5.52 |
| CHEMBL4561854 | — | — | 1 | 5.50 |
| CHEMBL4452210 | — | — | 1 | 5.46 |
| CHEMBL4453384 | — | — | 1 | 5.41 |
| CHEMBL4589260 | — | — | 1 | 5.37 |
| CHEMBL4536149 | — | — | 1 | 5.35 |
| CHEMBL4456764 | — | — | 1 | 5.30 |
| CHEMBL4579460 | — | — | 1 | 5.28 |
| CHEMBL4592731 | — | — | 1 | 5.27 |
| CHEMBL4446374 | — | — | 1 | 5.25 |
| CHEMBL4574513 | — | — | 1 | 5.24 |
| CHEMBL4547987 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573890 | — | IC50 | = | 88.6 | nM | 7.05 |
| CHEMBL4553953 | — | IC50 | = | 221.6 | nM | 6.65 |
| CHEMBL4458913 | — | IC50 | = | 262.7 | nM | 6.58 |
| CHEMBL4467890 | — | IC50 | = | 401.5 | nM | 6.40 |
| CHEMBL4448181 | — | IC50 | = | 542.6 | nM | 6.27 |
| CHEMBL4466950 | — | IC50 | = | 658.2 | nM | 6.18 |
| CHEMBL4458775 | — | IC50 | = | 667.8 | nM | 6.17 |
| CHEMBL4449741 | — | IC50 | = | 718.2 | nM | 6.14 |
| CHEMBL4447061 | — | IC50 | = | 839.4 | nM | 6.08 |
| CHEMBL4468419 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL4590914 | — | IC50 | = | 970.4 | nM | 6.01 |
| CHEMBL4520451 | — | IC50 | = | 1457.0 | nM | 5.84 |
| CHEMBL4592814 | — | IC50 | = | 1593.9 | nM | 5.80 |
| CHEMBL4518353 | — | IC50 | = | 1933.0 | nM | 5.71 |
| CHEMBL4545062 | — | IC50 | = | 2340.9 | nM | 5.63 |
| CHEMBL4437226 | — | IC50 | = | 2512.1 | nM | 5.60 |
| CHEMBL4557960 | — | IC50 | = | 2504.4 | nM | 5.60 |
| CHEMBL4584518 | — | IC50 | = | 2734.3 | nM | 5.56 |
| CHEMBL4527557 | — | IC50 | = | 2990.9 | nM | 5.52 |
| CHEMBL4561854 | — | IC50 | = | 3144.7 | nM | 5.50 |
| CHEMBL4452210 | — | IC50 | = | 3427.9 | nM | 5.46 |
| CHEMBL4453384 | — | IC50 | = | 3935.7 | nM | 5.41 |
| CHEMBL4589260 | — | IC50 | = | 4287.4 | nM | 5.37 |
| CHEMBL4536149 | — | IC50 | = | 4491.2 | nM | 5.35 |
| CHEMBL4456764 | — | IC50 | = | 5007.9 | nM | 5.30 |
| CHEMBL4579460 | — | IC50 | = | 5227.8 | nM | 5.28 |
| CHEMBL4592731 | — | IC50 | = | 5369.0 | nM | 5.27 |
| CHEMBL4446374 | — | IC50 | = | 5630.5 | nM | 5.25 |
| CHEMBL4574513 | — | IC50 | = | 5824.5 | nM | 5.24 |
| CHEMBL4547987 | — | IC50 | = | 6589.6 | nM | 5.18 |
| CHEMBL4461469 | — | IC50 | = | 6688.6 | nM | 5.17 |
| CHEMBL4457208 | — | IC50 | = | 7491.2 | nM | 5.12 |
| CHEMBL4553513 | — | IC50 | = | 7870.2 | nM | 5.10 |
| CHEMBL4453991 | — | IC50 | = | 8303.1 | nM | 5.08 |
| CHEMBL4445789 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4438018 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4454504 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4467067 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4444056 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4572771 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4439853 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4558108 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4531238 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4466570 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4578725 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4446114 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4548111 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4558719 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4570112 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4446168 | — | IC50 | = | 10000.0 | nM | 5.00 |