Assay Detail
Binding
CHEMBL4308764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSK (unknown origin) using fluorescent labeled peptide as substrate in presence of ATP at Km concentration by caliper method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.26 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4582324 | — | — | 1 | 8.70 |
| CHEMBL4443654 | — | — | 1 | 8.40 |
| CHEMBL4577049 | — | — | 1 | 8.40 |
| CHEMBL4545269 | — | — | 1 | 8.40 |
| CHEMBL4445994 | — | — | 1 | 8.40 |
| CHEMBL4537527 | — | — | 1 | 8.22 |
| CHEMBL4469360 | — | — | 1 | 7.89 |
| CHEMBL4483095 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4582324 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4443654 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4577049 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4545269 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4445994 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4537527 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4469360 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4483095 | — | IC50 | = | 21.0 | nM | 7.68 |