Assay Detail
Binding
CHEMBL4309010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channel current by two electrode voltage clamp method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.58 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435232 | — | — | 1 | 4.80 |
| CHEMBL1179605 | — | — | 1 | 4.48 |
| CHEMBL4452216 | — | — | 1 | 4.47 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | - |
| CHEMBL2397100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435232 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL1179605 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4452216 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL23194 | SPERMINE | EC50 | = | 127000.0 | nM | - |
| CHEMBL2397100 | — | EC50 | > | 10000.0 | nM | - |