Assay Detail

CHEMBL4309336

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Functional

Antiproliferative activity against human U87MG cells transfected with IDH1 R132H mutant

ChEMBL ↗

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Target

U-87 MG (CHEMBL614247) ↗

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U-87 MG (CHEMBL614247) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target U-87 MG

CHEMBL614247

Anchored from Assay target.

Protein identity U-87 MG

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-87MG ATCC
Confidence	1 — Organism
Curated By	Autocuration

Target

U-87 MG (CHEMBL614247) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective.

Ma T, Zou F, Pusch S, Xu Y, von Deimling A, Zha X.
J Med Chem (2018) 61 : 8981 -9003
PubMed 29847930 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.13	9.13

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4444886	—	—	1	9.13

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4444886	—	IC50	=	0.74	nM	9.13