Assay Detail
Binding
CHEMBL4309433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse kidney glutaminase assessed as ammonia formation at 0.1 uM using glutamine as substrate by Nessler's reagent based assay relative to control
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminase kidney isoform, mitochondrial (CHEMBL4523110) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.65 | 7.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4462220 | — | — | 1 | 7.30 |
| CHEMBL4537860 | — | — | 1 | 6.00 |
| CHEMBL4577734 | — | — | 1 | - |
| CHEMBL4452754 | — | — | 1 | - |
| CHEMBL4540444 | — | — | 1 | - |
| CHEMBL4441898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4462220 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4537860 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4577734 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4452754 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4540444 | — | IC50 | < | 25.0 | nM | - |
| CHEMBL4441898 | — | Inhibition | <= | 25.0 | % | - |