Assay Detail
Binding
CHEMBL4309982
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Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.56 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474459 | — | — | 1 | 7.89 |
| CHEMBL1802728 | — | — | 1 | 7.46 |
| CHEMBL393929 | — | — | 1 | 6.09 |
| CHEMBL261425 | — | — | 1 | 4.81 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474459 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1802728 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL393929 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL261425 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL572878 | TOZASERTIB | IC50 | - | — | - |