Assay Detail
Binding
CHEMBL4310083
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Inhibition of BRD4 bromodomain 1 (unknown origin) expressed in Escherichia coli Bl21(DE3) by fluorescence anisotropy
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.45 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4452281 | — | — | 1 | 5.89 |
| CHEMBL4521096 | — | — | 1 | 5.77 |
| CHEMBL13880 | — | — | 1 | 5.54 |
| CHEMBL417255 | — | — | 1 | 5.43 |
| CHEMBL14682 | — | — | 1 | 4.62 |
| CHEMBL14339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4452281 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4521096 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL13880 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL417255 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL14682 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL14339 | — | IC50 | > | 250000.0 | nM | - |