Assay Detail
Binding
CHEMBL4310084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BRDT bromodomain 1 (unknown origin) expressed in Escherichia coli Bl21(DE3) by fluorescence anisotropy
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain testis-specific protein (CHEMBL1795185) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.90 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4521096 | — | — | 1 | 5.46 |
| CHEMBL4452281 | — | — | 1 | 5.33 |
| CHEMBL13880 | — | — | 1 | 4.89 |
| CHEMBL417255 | — | — | 1 | 4.75 |
| CHEMBL14682 | — | — | 1 | 4.06 |
| CHEMBL14339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4521096 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4452281 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL13880 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL417255 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL14682 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL14339 | — | IC50 | > | 250000.0 | nM | - |