Assay Detail
Binding
CHEMBL4310093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD2 N-terminal bromodomain 1 (unknown origin) expressed in Escherichia coli Bl21(DE3) by alpha-screen assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.89 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441390 | — | — | 1 | 5.75 |
| CHEMBL4521096 | — | — | 1 | 4.54 |
| CHEMBL4475135 | — | — | 1 | 4.37 |
| CHEMBL4533090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441390 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4521096 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4475135 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4533090 | — | IC50 | > | 250000.0 | nM | - |