Assay Detail
Binding
CHEMBL4310094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD2 C-terminal bromodomain 2 (unknown origin) expressed in Escherichia coli Bl21(DE3) by alpha-screen assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.54 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441390 | — | — | 1 | 4.92 |
| CHEMBL4475135 | — | — | 1 | 4.52 |
| CHEMBL4521096 | — | — | 1 | 4.17 |
| CHEMBL4533090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441390 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4475135 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4521096 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4533090 | — | IC50 | = | 260000.0 | nM | - |