Assay Detail

CHEMBL4310786

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Functional

Anti-parasitic activity against Trypanosoma brucei rhodesiense STIB 851

ChEMBL ↗

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Target

Trypanosoma brucei rhodesiense (CHEMBL612348) ↗

Open DB target context

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Trypanosoma brucei rhodesiense (CHEMBL612348) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma brucei rhodesiense

CHEMBL612348

Anchored from Assay target.

Protein identity Trypanosoma brucei rhodesiense

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma brucei rhodesiense
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348) ↗

Type	ORGANISM
Organism	Trypanosoma brucei rhodesiense

Publication

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.

Scarim CB, Jornada DH, Machado MGM, Ferreira CMR, Dos Santos JL, Chung MC.
Eur J Med Chem (2019) 162 : 378 -395
PubMed 30453246 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.58	6.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL45152	—	—	1	6.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL45152	—	IC50	=	263.0	nM	6.58