Assay Detail
Binding
CHEMBL4310908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C-terminal His-tagged HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.16 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437833 | — | — | 1 | 7.80 |
| CHEMBL4456445 | — | — | 1 | 7.22 |
| CHEMBL3110003 | — | — | 1 | 6.82 |
| CHEMBL396097 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437833 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4456445 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3110003 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL396097 | — | IC50 | = | 160.0 | nM | 6.80 |