Assay Detail
Binding
CHEMBL4310909
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Inhibition of HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.35 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4533107 | — | — | 1 | 7.77 |
| CHEMBL4461062 | — | — | 1 | 7.66 |
| CHEMBL4472392 | — | — | 1 | 7.66 |
| CHEMBL4457713 | — | — | 1 | 7.66 |
| CHEMBL4454327 | — | — | 1 | 7.60 |
| CHEMBL4581271 | — | — | 1 | 7.60 |
| CHEMBL4546422 | — | — | 1 | 7.60 |
| CHEMBL4535902 | — | — | 1 | 7.52 |
| CHEMBL4438812 | — | — | 1 | 7.51 |
| CHEMBL4447877 | — | — | 1 | 7.48 |
| CHEMBL4437833 | — | — | 1 | 7.44 |
| CHEMBL4577004 | — | — | 1 | 7.40 |
| CHEMBL4572214 | — | — | 1 | 7.31 |
| CHEMBL4456445 | — | — | 1 | 7.27 |
| CHEMBL4531880 | — | — | 1 | 7.26 |
| CHEMBL4558414 | — | — | 1 | 7.24 |
| CHEMBL4452941 | — | — | 1 | 6.99 |
| CHEMBL4469204 | — | — | 1 | 6.92 |
| CHEMBL396097 | — | — | 1 | 6.60 |
| CHEMBL3110003 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4533107 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4461062 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4472392 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4457713 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4454327 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4581271 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4546422 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4535902 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4438812 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4447877 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4437833 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4577004 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4572214 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4456445 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4531880 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4558414 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4452941 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4469204 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL396097 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3110003 | — | IC50 | = | 330.0 | nM | 6.48 |