Assay Detail
Binding
CHEMBL4311550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.23 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464732 | — | — | 1 | 5.53 |
| CHEMBL485818 | BAICALIN | — | 1 | 5.45 |
| CHEMBL16171 | WOGONIN | — | 1 | 5.05 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464732 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL485818 | BAICALIN | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL16171 | WOGONIN | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 12500.0 | nM | 4.90 |