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Assay Detail

CHEMBL4311608

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Binding
Binding affinity to recombinant human CA4 assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 4 (CHEMBL3729) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases.
Vaškevičienė I, Paketurytė V, Pajanok N, Žukauskas Š, Sapijanskaitė B, Kantminienė K, Mickevičius V, Zubrienė A, Matulis D.
Bioorg Med Chem (2019) 27 : 322 -337
PubMed 30553625 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 40 9.45 10.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4441730 — — 1 10.21
CHEMBL4553790 — — 1 10.05
CHEMBL4449149 — — 1 10.03
CHEMBL4558235 — — 1 10.00
CHEMBL4475315 — — 1 9.92
CHEMBL4452277 — — 1 9.89
CHEMBL4555622 — — 1 9.77
CHEMBL4462447 — — 1 9.74
CHEMBL4458989 — — 1 9.74
CHEMBL4573916 — — 1 9.74
CHEMBL4516072 — — 1 9.72
CHEMBL4474251 — — 1 9.66
CHEMBL4560953 — — 1 9.66
CHEMBL4474833 — — 1 9.64
CHEMBL4567746 — — 1 9.57
CHEMBL4463683 — — 1 9.57
CHEMBL4439909 — — 1 9.57
CHEMBL4567916 — — 1 9.55
CHEMBL4441652 — — 1 9.51
CHEMBL4448119 — — 1 9.51
CHEMBL4570253 — — 1 9.49
CHEMBL4577993 — — 1 9.49
CHEMBL4558457 — — 1 9.49
CHEMBL4473602 — — 1 9.44
CHEMBL4593434 — — 1 9.40
CHEMBL4590754 — — 1 9.38
CHEMBL4449430 — — 1 9.38
CHEMBL4517728 — — 1 9.35
CHEMBL4446249 — — 1 9.35
CHEMBL4587295 — — 1 9.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4441730 — Kd = 0.062 nM 10.21
CHEMBL4553790 — Kd = 0.089 nM 10.05
CHEMBL4449149 — Kd = 0.093 nM 10.03
CHEMBL4558235 — Kd = 0.1 nM 10.00
CHEMBL4475315 — Kd = 0.12 nM 9.92
CHEMBL4452277 — Kd = 0.13 nM 9.89
CHEMBL4555622 — Kd = 0.17 nM 9.77
CHEMBL4462447 — Kd = 0.18 nM 9.74
CHEMBL4458989 — Kd = 0.18 nM 9.74
CHEMBL4573916 — Kd = 0.18 nM 9.74
CHEMBL4516072 — Kd = 0.19 nM 9.72
CHEMBL4474251 — Kd = 0.22 nM 9.66
CHEMBL4560953 — Kd = 0.22 nM 9.66
CHEMBL4474833 — Kd = 0.23 nM 9.64
CHEMBL4439909 — Kd = 0.27 nM 9.57
CHEMBL4567746 — Kd = 0.27 nM 9.57
CHEMBL4463683 — Kd = 0.27 nM 9.57
CHEMBL4567916 — Kd = 0.28 nM 9.55
CHEMBL4441652 — Kd = 0.31 nM 9.51
CHEMBL4448119 — Kd = 0.31 nM 9.51
CHEMBL4570253 — Kd = 0.32 nM 9.49
CHEMBL4558457 — Kd = 0.32 nM 9.49
CHEMBL4577993 — Kd = 0.32 nM 9.49
CHEMBL4473602 — Kd = 0.36 nM 9.44
CHEMBL4593434 — Kd = 0.4 nM 9.40
CHEMBL4590754 — Kd = 0.42 nM 9.38
CHEMBL4449430 — Kd = 0.42 nM 9.38
CHEMBL4517728 — Kd = 0.45 nM 9.35
CHEMBL4446249 — Kd = 0.45 nM 9.35
CHEMBL4587295 — Kd = 0.83 nM 9.08
CHEMBL4443078 — Kd = 0.91 nM 9.04
CHEMBL4570038 — Kd = 1.3 nM 8.89
CHEMBL4444784 — Kd = 1.6 nM 8.80
CHEMBL4465027 — Kd = 2.2 nM 8.66
CHEMBL4454574 — Kd = 3.0 nM 8.52
CHEMBL4555586 — Kd = 3.7 nM 8.43
CHEMBL4577083 — Kd = 4.1 nM 8.39
CHEMBL4464359 — Kd - — -
CHEMBL4461481 — Kd - — -
CHEMBL4516858 — Kd - — -