Assay Detail
Functional
CHEMBL4313087
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Antiproliferative activity against human SNU16 cells measured after 72 hrs by CCK8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Development of a Series of Pyrazolo[3,4-<i>d</i>]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.60 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541330 | — | — | 1 | 8.89 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.31 |
| CHEMBL4446835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541330 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4446835 | — | IC50 | < | 0.3 | nM | - |