Assay Detail
Binding
CHEMBL4313396
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Inhibition of recombinant Nanoluc-tagged p38alpha (unknown origin) expressed in HEK293 cells incubated for 2 to 3 mins by NanoBRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.39 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 7.22 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.33 |
| CHEMBL4553144 | — | — | 1 | 6.28 |
| CHEMBL4559825 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5416410 | DASATINIB | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4553144 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4559825 | — | EC50 | = | 1940.0 | nM | 5.71 |