Assay Detail
Binding
CHEMBL4313574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine brain tubulin polymerization assessed as decrease in fluorescence intensity measured every 60 sec for 90 mins in presence of GTP by DAPI staining based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.14 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.28 |
| CHEMBL4530425 | — | — | 1 | 6.16 |
| CHEMBL4472670 | — | — | 1 | 6.12 |
| CHEMBL4463939 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4530425 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4472670 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4463939 | — | IC50 | = | 1030.0 | nM | 5.99 |