Assay Detail
Functional
CHEMBL4313576
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Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.27 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463939 | — | — | 1 | 8.40 |
| CHEMBL4578672 | — | — | 1 | 8.00 |
| CHEMBL4459432 | — | — | 1 | 6.80 |
| CHEMBL4530425 | — | — | 1 | 6.64 |
| CHEMBL4559879 | — | — | 1 | 6.52 |
| CHEMBL4469366 | — | — | 1 | 6.44 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.25 |
| CHEMBL4529269 | — | — | 1 | 6.22 |
| CHEMBL4438232 | — | — | 1 | 6.21 |
| CHEMBL4573516 | — | — | 1 | 6.16 |
| CHEMBL4472082 | — | — | 1 | 6.10 |
| CHEMBL4455365 | — | — | 1 | 6.09 |
| CHEMBL4469552 | — | — | 1 | 6.00 |
| CHEMBL4528338 | — | — | 1 | 5.93 |
| CHEMBL4541423 | — | — | 1 | 5.88 |
| CHEMBL4529613 | — | — | 1 | 5.74 |
| CHEMBL4553392 | — | — | 1 | 5.65 |
| CHEMBL4472670 | — | — | 1 | 5.58 |
| CHEMBL4570545 | — | — | 1 | 5.43 |
| CHEMBL4579484 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463939 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4578672 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4459432 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4530425 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4559879 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4469366 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4529269 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4438232 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4573516 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4472082 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4455365 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4469552 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4528338 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL4541423 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4529613 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4553392 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4472670 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4570545 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL4579484 | — | IC50 | = | 5470.0 | nM | 5.26 |