Assay Detail
Functional
CHEMBL4313653
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Antiproliferative against human UO31 cells incubated for 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UO-31 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.56 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4535881 | — | — | 1 | 8.24 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.13 |
| CHEMBL4561572 | — | — | 1 | 8.06 |
| CHEMBL4569755 | — | — | 1 | 7.87 |
| CHEMBL4465282 | — | — | 1 | 7.53 |
| CHEMBL1322701 | — | — | 1 | 7.48 |
| CHEMBL3098650 | — | — | 1 | 7.43 |
| CHEMBL4456191 | — | — | 1 | 7.28 |
| CHEMBL4529762 | — | — | 1 | 7.08 |
| CHEMBL4533452 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4535881 | — | IC50 | = | 5.759 | nM | 8.24 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.453 | nM | 8.13 |
| CHEMBL4561572 | — | IC50 | = | 8.604 | nM | 8.06 |
| CHEMBL4569755 | — | IC50 | = | 13.57 | nM | 7.87 |
| CHEMBL4465282 | — | IC50 | = | 29.63 | nM | 7.53 |
| CHEMBL1322701 | — | IC50 | = | 33.15 | nM | 7.48 |
| CHEMBL3098650 | — | IC50 | = | 36.72 | nM | 7.43 |
| CHEMBL4456191 | — | IC50 | = | 52.66 | nM | 7.28 |
| CHEMBL4529762 | — | IC50 | = | 83.51 | nM | 7.08 |
| CHEMBL4533452 | — | IC50 | = | 310.04 | nM | 6.51 |