Assay Detail
Binding
CHEMBL4313654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin peptide as substrate measured after 10 mins by HTRF assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.32 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4535881 | — | — | 1 | 6.56 |
| CHEMBL4561572 | — | — | 1 | 6.38 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.38 |
| CHEMBL4569755 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4535881 | — | IC50 | = | 275.7 | nM | 6.56 |
| CHEMBL4561572 | — | IC50 | = | 412.3 | nM | 6.38 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 417.8 | nM | 6.38 |
| CHEMBL4569755 | — | IC50 | = | 1128.9 | nM | 5.95 |