Assay Detail
Binding
CHEMBL4313752
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Inhibition of recombinant human Cdc25C using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.56 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4521092 | — | — | 1 | 7.05 |
| CHEMBL4566962 | — | — | 1 | 6.68 |
| CHEMBL4466461 | — | — | 1 | 6.38 |
| CHEMBL337173 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4521092 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4566962 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4466461 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL337173 | — | IC50 | = | 760.0 | nM | 6.12 |