Assay Detail
Functional
CHEMBL4313758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTS assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.57 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.60 |
| CHEMBL4573023 | — | — | 1 | 7.41 |
| CHEMBL4446571 | — | — | 1 | 6.98 |
| CHEMBL4578720 | — | — | 1 | 6.88 |
| CHEMBL4442567 | — | — | 1 | 6.84 |
| CHEMBL4451293 | — | — | 1 | 6.80 |
| CHEMBL4567016 | — | — | 1 | 6.60 |
| CHEMBL4536674 | — | — | 1 | 6.59 |
| CHEMBL4531200 | — | — | 1 | 6.50 |
| CHEMBL4472814 | — | — | 1 | 6.48 |
| CHEMBL4436106 | — | — | 1 | 6.47 |
| CHEMBL4483453 | — | — | 1 | 6.38 |
| CHEMBL4546163 | — | — | 1 | 6.32 |
| CHEMBL4559846 | — | — | 1 | 6.26 |
| CHEMBL4461103 | — | — | 1 | 6.16 |
| CHEMBL4549368 | — | — | 1 | 6.06 |
| CHEMBL4473686 | — | — | 1 | 6.05 |
| CHEMBL4562450 | — | — | 1 | 5.90 |
| CHEMBL4435547 | — | — | 1 | 5.71 |
| CHEMBL4466026 | — | — | 1 | 5.42 |
| CHEMBL4465148 | — | — | 1 | - |
| CHEMBL4574055 | — | — | 1 | - |
| CHEMBL4467635 | — | — | 1 | - |
| CHEMBL4547033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.251 | nM | 9.60 |
| CHEMBL4573023 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL4446571 | — | IC50 | = | 103.7 | nM | 6.98 |
| CHEMBL4578720 | — | IC50 | = | 132.5 | nM | 6.88 |
| CHEMBL4442567 | — | IC50 | = | 143.9 | nM | 6.84 |
| CHEMBL4451293 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4567016 | — | IC50 | = | 250.4 | nM | 6.60 |
| CHEMBL4536674 | — | IC50 | = | 254.2 | nM | 6.59 |
| CHEMBL4531200 | — | IC50 | = | 316.1 | nM | 6.50 |
| CHEMBL4472814 | — | IC50 | = | 328.9 | nM | 6.48 |
| CHEMBL4436106 | — | IC50 | = | 341.8 | nM | 6.47 |
| CHEMBL4483453 | — | IC50 | = | 418.5 | nM | 6.38 |
| CHEMBL4546163 | — | IC50 | = | 483.2 | nM | 6.32 |
| CHEMBL4559846 | — | IC50 | = | 555.1 | nM | 6.26 |
| CHEMBL4461103 | — | IC50 | = | 684.8 | nM | 6.16 |
| CHEMBL4549368 | — | IC50 | = | 862.2 | nM | 6.06 |
| CHEMBL4473686 | — | IC50 | = | 887.2 | nM | 6.05 |
| CHEMBL4562450 | — | IC50 | = | 1268.0 | nM | 5.90 |
| CHEMBL4435547 | — | IC50 | = | 1959.0 | nM | 5.71 |
| CHEMBL4466026 | — | IC50 | = | 3785.0 | nM | 5.42 |
| CHEMBL4465148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4574055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547033 | — | IC50 | > | 10000.0 | nM | - |