Assay Detail
Functional
CHEMBL4313759
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Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTS assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.72 | 9.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.63 |
| CHEMBL4573023 | — | — | 1 | 7.23 |
| CHEMBL4536674 | — | — | 1 | 6.96 |
| CHEMBL4446571 | — | — | 1 | 6.82 |
| CHEMBL4559846 | — | — | 1 | 6.62 |
| CHEMBL4567016 | — | — | 1 | 6.60 |
| CHEMBL4442567 | — | — | 1 | 6.57 |
| CHEMBL4436106 | — | — | 1 | 6.44 |
| CHEMBL4461103 | — | — | 1 | 6.40 |
| CHEMBL4546163 | — | — | 1 | 6.37 |
| CHEMBL4483453 | — | — | 1 | 6.36 |
| CHEMBL4562450 | — | — | 1 | 6.34 |
| CHEMBL4578720 | — | — | 1 | 6.17 |
| CHEMBL4451293 | — | — | 1 | 6.16 |
| CHEMBL4531200 | — | — | 1 | 6.08 |
| CHEMBL4435547 | — | — | 1 | - |
| CHEMBL4547033 | — | — | 1 | - |
| CHEMBL4466026 | — | — | 1 | - |
| CHEMBL4472814 | — | — | 1 | - |
| CHEMBL4574055 | — | — | 1 | - |
| CHEMBL4467635 | — | — | 1 | - |
| CHEMBL4473686 | — | — | 1 | - |
| CHEMBL4549368 | — | — | 1 | - |
| CHEMBL4465148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.232 | nM | 9.63 |
| CHEMBL4573023 | — | IC50 | = | 58.4 | nM | 7.23 |
| CHEMBL4536674 | — | IC50 | = | 110.6 | nM | 6.96 |
| CHEMBL4446571 | — | IC50 | = | 150.7 | nM | 6.82 |
| CHEMBL4559846 | — | IC50 | = | 242.6 | nM | 6.62 |
| CHEMBL4567016 | — | IC50 | = | 252.7 | nM | 6.60 |
| CHEMBL4442567 | — | IC50 | = | 271.8 | nM | 6.57 |
| CHEMBL4436106 | — | IC50 | = | 364.8 | nM | 6.44 |
| CHEMBL4461103 | — | IC50 | = | 401.6 | nM | 6.40 |
| CHEMBL4546163 | — | IC50 | = | 426.4 | nM | 6.37 |
| CHEMBL4483453 | — | IC50 | = | 437.7 | nM | 6.36 |
| CHEMBL4562450 | — | IC50 | = | 461.8 | nM | 6.34 |
| CHEMBL4578720 | — | IC50 | = | 668.9 | nM | 6.17 |
| CHEMBL4451293 | — | IC50 | = | 684.9 | nM | 6.16 |
| CHEMBL4531200 | — | IC50 | = | 831.1 | nM | 6.08 |
| CHEMBL4435547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547033 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4466026 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4472814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4574055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4473686 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4549368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4465148 | — | IC50 | > | 10000.0 | nM | - |