Assay Detail
Functional
CHEMBL4315426
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Cytoprotection against glutamate/glycine-induced cytotoxicity against mouse LTK cells expressing GluN1a/GluN2B preincubated 30 mins followed by glutamate/glycine addition and measured after 6 hrs by LDH assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.41 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305195 | — | — | 1 | 7.89 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 6.60 |
| CHEMBL4473586 | — | — | 1 | 6.24 |
| CHEMBL4561134 | — | — | 1 | 5.80 |
| CHEMBL4284348 | — | — | 1 | 5.52 |
| CHEMBL4286654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305195 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL305187 | IFENPRODIL | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4473586 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4561134 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4284348 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4286654 | — | IC50 | > | 10000.0 | nM | - |