Assay Detail
Functional
CHEMBL4316285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U87MG cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
15
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.38 | 7.52 |
| Inhibition | 5 | - | - |
| Emax | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4543075 | — | — | 3 | 7.52 |
| CHEMBL4559506 | — | — | 3 | 7.51 |
| CHEMBL4586068 | — | — | 3 | 7.34 |
| CHEMBL4536640 | — | — | 3 | 7.32 |
| CHEMBL4444616 | — | — | 3 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4543075 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL4559506 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL4586068 | — | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL4536640 | — | IC50 | = | 47.6 | nM | 7.32 |
| CHEMBL4444616 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4444616 | — | Inhibition | - | % | - | |
| CHEMBL4444616 | — | Emax | = | 22.0 | % | - |
| CHEMBL4543075 | — | Inhibition | - | % | - | |
| CHEMBL4543075 | — | Emax | = | 32.4 | % | - |
| CHEMBL4559506 | — | Emax | = | 32.0 | % | - |
| CHEMBL4559506 | — | Inhibition | - | % | - | |
| CHEMBL4586068 | — | Emax | = | 32.0 | % | - |
| CHEMBL4586068 | — | Inhibition | - | % | - | |
| CHEMBL4536640 | — | Emax | = | 31.8 | % | - |
| CHEMBL4536640 | — | Inhibition | - | % | - |