Assay Detail
Binding
CHEMBL4316484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 81 | 7.29 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442511 | — | — | 1 | 9.12 |
| CHEMBL4543024 | — | — | 1 | 8.96 |
| CHEMBL4578934 | — | — | 1 | 8.77 |
| CHEMBL4586089 | — | — | 1 | 8.64 |
| CHEMBL4562296 | — | — | 1 | 8.52 |
| CHEMBL4446052 | — | — | 1 | 8.48 |
| CHEMBL4451500 | — | — | 1 | 8.43 |
| CHEMBL4517317 | — | — | 1 | 8.35 |
| CHEMBL4551069 | — | — | 1 | 8.28 |
| CHEMBL4437818 | — | — | 1 | 8.21 |
| CHEMBL4450456 | — | — | 1 | 8.21 |
| CHEMBL4466140 | — | — | 1 | 8.15 |
| CHEMBL4539233 | — | — | 1 | 8.12 |
| CHEMBL4436290 | — | — | 1 | 8.12 |
| CHEMBL4450545 | — | — | 1 | 8.04 |
| CHEMBL4456084 | — | — | 1 | 8.03 |
| CHEMBL4573963 | — | — | 1 | 8.00 |
| CHEMBL4468834 | — | — | 1 | 8.00 |
| CHEMBL4574321 | — | — | 1 | 8.00 |
| CHEMBL4444201 | — | — | 1 | 8.00 |
| CHEMBL4451503 | — | — | 1 | 7.96 |
| CHEMBL4565224 | — | — | 1 | 7.92 |
| CHEMBL4456851 | — | — | 1 | 7.89 |
| CHEMBL4475073 | — | — | 1 | 7.82 |
| CHEMBL4468310 | — | — | 1 | 7.77 |
| CHEMBL4588838 | — | — | 1 | 7.75 |
| CHEMBL4573894 | — | — | 1 | 7.75 |
| CHEMBL4572161 | — | — | 1 | 7.72 |
| CHEMBL4569008 | — | — | 1 | 7.66 |
| CHEMBL4441818 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442511 | — | Kd | = | 0.76 | nM | 9.12 |
| CHEMBL4543024 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4578934 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4586089 | — | Kd | = | 2.3 | nM | 8.64 |
| CHEMBL4562296 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL4446052 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL4451500 | — | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL4517317 | — | Kd | = | 4.5 | nM | 8.35 |
| CHEMBL4551069 | — | Kd | = | 5.2 | nM | 8.28 |
| CHEMBL4437818 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL4450456 | — | Kd | = | 6.2 | nM | 8.21 |
| CHEMBL4466140 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL4539233 | — | Kd | = | 7.6 | nM | 8.12 |
| CHEMBL4436290 | — | Kd | = | 7.6 | nM | 8.12 |
| CHEMBL4450545 | — | Kd | = | 9.2 | nM | 8.04 |
| CHEMBL4456084 | — | Kd | = | 9.3 | nM | 8.03 |
| CHEMBL4573963 | — | Kd | = | 9.9 | nM | 8.00 |
| CHEMBL4468834 | — | Kd | = | 9.9 | nM | 8.00 |
| CHEMBL4574321 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4444201 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4451503 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL4565224 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4456851 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL4475073 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL4468310 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL4588838 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL4573894 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL4572161 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL4569008 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL4441818 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL4515586 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL4593681 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL4513684 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4583164 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL4576689 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL4558287 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL4470832 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL4450306 | — | Kd | = | 54.0 | nM | 7.27 |
| CHEMBL4475496 | — | Kd | = | 62.0 | nM | 7.21 |
| CHEMBL4466735 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL4454599 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL4463844 | — | Kd | = | 69.0 | nM | 7.16 |
| CHEMBL4459385 | — | Kd | = | 74.0 | nM | 7.13 |
| CHEMBL4465972 | — | Kd | = | 76.0 | nM | 7.12 |
| CHEMBL4165127 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL4582964 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL4565560 | — | Kd | = | 92.0 | nM | 7.04 |
| CHEMBL4553519 | — | Kd | = | 92.0 | nM | 7.04 |
| CHEMBL4514121 | — | Kd | = | 99.0 | nM | 7.00 |
| CHEMBL4469236 | — | Kd | = | 99.0 | nM | 7.00 |