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Assay Detail

CHEMBL4316736

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 24 hrs by sulforhodamine B assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

In Vitro and in Vivo Antitumor Effects of Plant-Derived Miliusanes and Their Induction of Cellular Senescence.
Xu XY, Tsang SW, Guan YF, Liu KL, Pan WH, Lam CS, Lee KM, Xia YX, Xie WJ, Wong WY, Lee MML, Tai WCS, Zhang HJ.
J Med Chem (2019) 62 : 1541 -1561
PubMed 30633861 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.32 5.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4513733 1 5.71
CHEMBL4588940 1 5.59
CHEMBL4572584 1 5.53
CHEMBL4513721 1 5.46
CHEMBL382849 1 5.43
CHEMBL440759 1 5.41
CHEMBL4515263 1 5.16
CHEMBL4528773 1 5.14
CHEMBL4458136 1 4.89
CHEMBL4462375 1 4.85
CHEMBL4520288 1 -
CHEMBL4556341 1 -
CHEMBL4579804 1 -
CHEMBL4558393 1 -
CHEMBL4544753 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4513733 IC50 = 1950.0 nM 5.71
CHEMBL4588940 IC50 = 2570.0 nM 5.59
CHEMBL4572584 IC50 = 2930.0 nM 5.53
CHEMBL4513721 IC50 = 3430.0 nM 5.46
CHEMBL382849 IC50 = 3670.0 nM 5.43
CHEMBL440759 IC50 = 3940.0 nM 5.41
CHEMBL4515263 IC50 = 6970.0 nM 5.16
CHEMBL4528773 IC50 = 7180.0 nM 5.14
CHEMBL4458136 IC50 = 12900.0 nM 4.89
CHEMBL4462375 IC50 = 14000.0 nM 4.85
CHEMBL4520288 IC50 > 30000.0 nM -
CHEMBL4556341 IC50 > 30000.0 nM -
CHEMBL4579804 IC50 > 30000.0 nM -
CHEMBL4558393 IC50 > 30000.0 nM -
CHEMBL4544753 IC50 > 30000.0 nM -