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Assay Detail

CHEMBL4320888

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to ABL1 (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase ABL1 (CHEMBL1862)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes.
Bauer MR, Mackey MD.
J Med Chem (2019) 62 : 3036 -3050
PubMed 30807144 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 9.00 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL941 IMATINIB 4.0 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL941 IMATINIB Kd = 1.0 nM 9.00