Assay Detail
Binding
CHEMBL4322122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Why Some Targets Benefit from beyond Rule of Five Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.54 | 8.70 |
| IC50 | 1 | 6.89 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522038 | XIMELAGATRAN | 4.0 | 1 | 8.70 |
| CHEMBL114715 | INOGATRAN | 2.0 | 1 | 8.38 |
| CHEMBL1229657 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522038 | XIMELAGATRAN | Ki | = | 2.01 | nM | 8.70 |
| CHEMBL114715 | INOGATRAN | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL1229657 | — | IC50 | = | 130.0 | nM | 6.89 |