Assay Detail
Binding
CHEMBL4322624
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Schistosoma mansoni sirtuin 2 (21 to 322 residues) expressed in Escherichia coli BL21(DE3) cells using ZMAL as substrate after 1 hr in presence of NAD+ by homogeneous fluorescence based analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase (CHEMBL4523517) ↗| Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
Publication
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.94 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252556 | IDEBENONE | 4.0 | 1 | 5.72 |
| CHEMBL4444104 | — | — | 1 | 5.70 |
| CHEMBL4442390 | — | — | 1 | 5.63 |
| CHEMBL4567519 | — | — | 1 | 5.48 |
| CHEMBL4461910 | — | — | 1 | 5.37 |
| CHEMBL4577629 | — | — | 1 | 4.90 |
| CHEMBL4459211 | — | — | 1 | 4.89 |
| CHEMBL3431191 | — | — | 1 | 4.85 |
| CHEMBL4526249 | — | — | 1 | 4.83 |
| CHEMBL3430999 | — | — | 1 | 4.74 |
| CHEMBL4529336 | — | — | 1 | 4.64 |
| CHEMBL3431127 | — | — | 1 | 4.62 |
| CHEMBL4571708 | — | — | 1 | 4.56 |
| CHEMBL4533566 | — | — | 1 | 4.51 |
| CHEMBL4579496 | — | — | 1 | 4.35 |
| CHEMBL4562238 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252556 | IDEBENONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4444104 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4442390 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4567519 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4461910 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4577629 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4459211 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL3431191 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4526249 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3430999 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4529336 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL3431127 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL4571708 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL4533566 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL4579496 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL4562238 | — | IC50 | = | 65100.0 | nM | 4.19 |