Assay Detail
ADMET
CHEMBL4322644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human sirtuin 2 (25 to 389 residues) assessed as inhibition of substrate deacetylation using ZMAL as substrate incubated for 4 hrs by fluorescene-based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.92 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770903 | — | — | 1 | 6.40 |
| CHEMBL3769988 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770903 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3769988 | — | IC50 | = | 3700.0 | nM | 5.43 |