Assay Detail
ADMET
CHEMBL4322646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6 tagged human sirtuin 2 (25 to 389 residues) using Cbz-Lys(acetyl)-AMC as substrate after 4 hrs in presence of NAD+ by homogeneous fluorescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.85 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3431191 | — | — | 1 | 5.44 |
| CHEMBL4526249 | — | — | 1 | 4.88 |
| CHEMBL252556 | IDEBENONE | 4.0 | 1 | 4.81 |
| CHEMBL4444104 | — | — | 1 | 4.67 |
| CHEMBL4459211 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3431191 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4526249 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL252556 | IDEBENONE | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4444104 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL4459211 | — | IC50 | = | 36700.0 | nM | 4.43 |